Cholera is an acute, diarrheal disease caused by the bacterium
Vibrio cholerae, in most cases, from contaminated water. It may be mild
Where is cholera usually found?
is now very rare in industrialized nations; the last serious outbreak in the US
occurred in 1911. However, the disease is still endemic in the developing world,
including the Indian subcontinent and sub-Saharan Africa.
common is cholera?
In areas with inadequate sanitation, cholera is endemic.
Many prefer to refer to a 30 year epidemic, on the basis that the disease does
change with time, and spreads in waves from country to country. But the the underlying
links between disease and untreated water is perennial and unchanging. The incidence
in central America and Asia is declining, but major improvements in sewage and
water systems will be required in many developing countries before the word 'eradication'
can be considered. Only in the last few years have charities and governments recognized
that water treatment is a vital component of any aid package; not just for cholera,
but for a slate of water-borne diseases.
is cholera transmitted?
Cholera occurs naturally in water-borne life, such
as plankton, and so is initially ingested by drinking contaminated water, or eating
uncooked fish or seafood from such water.
Cholera is then transmitted feces
contaminated with the bacterium. This may occur when untreated sewage is released
into waterways or groundwater, further contaminating the water and food taken
from it or washed in it.
Can cholera be spread from
Direct person-to-person spread is unlikely, but poor
hygiene practices, particluarly with the resulting diarrhea, can result in direct
contamination of food or water used by others. This is how epidemics begin; the
disease can spread rapidly in areas with a combination of poor education, untreated
water and inadequate treatment of sewage.
Who is most
at risk from cholera?
The prime risk factor is being in an area which has
endemic cholera or poor water and sewage facilities. While few 'westerners' are
at serious risk, careless or unthinking travellers to such areas do have an increased
risk, and regularly bring the disease home.
Susceptibility to cholera depends
on many individual factors, but four features significantly increase risk:
large amount of the bacteria need to be ingested for infection to occur; repeated
drinking of contaminated water will increase the risk.
- Those with weakened
immune systems, including older people and infants.
- Risk is affected by
blood type. People with type O blood are most susceptible, then B, then A; those
with type AB are least likely to be affected.
- Increased susceptibility
has been observed in those with lower gastric acidity, either from antacids or
The risks vary in inverse proportion to the resources
available for disease management; the reported overall 'case-fatality rate' (CFR)
has dropped to about 1.5% overall, but while the CFR for South Africa is very
low (about 0.25%), rates of up to 30% have been observed in other parts of Africa.
are the symptoms of cholera?
Cholera is characterized by sudden, painless,
profuse watery diarrhea and vomiting. The amount of fluid lost may be considerable,
and is in proportion to the severity of the infection. In severe infections, the
diarrhea can causes a fluid loss of more than one litre per hour. Within hours,
severe dehydration, with intense thirst, muscle cramp, weakness, and negligable
urine production will usually follow. Untreated choleral dehydration may lead
to kidney failure, shock, coma, and death.
Symptoms usually subside in a
few days, and most people are free of the bacteria in two weeks, but a few become
Symptoms are largely confined to the intestines, and
the diarrhea is caused by the enterotoxins that V. cholerae produces. The
effects may be mild and transient, but in about one in 20 infected people, the
disease will progress as described above.
What are the
long term effects of cholera?
The debilitating effects of the disease may
take a considerable time to resolve; in a few cases, irreversible kidney failure
may be a result of dehydration.
What is the mortality
rate for cholera?
Cholera has a short incubation period, 2-3 days, and
can be rapidly fatal if untreated. The death rate may be as high as 50%, and some
epidemics ahve had a 90% mortality rate. But with effective treatment, mortality
is less than 1%.
For comparison, the 1849 St. Louis epidemic resulted in
4,557 deaths in a population of 63,000. That's just 7.2% of the total population,
many years before effective treatment was devised; but that figure may be misleading,
as we do not know how many people actually contracted the disease.
is cholera diagnosed?
The disease starts has a distinctive pattern, and
diagnosis will initially be made by clinical signs of a patient in a cholera area.
diagnosis will be confirmed by culturing bacteria from rectal swabs or fresh stool
Dipsticks have been developed for rapid diagnosis, enabling a diagnosis
within a few minutes.
Is there a treatment for
Immediate rehydration is the key to management of cholera. It
is the loss of fluid and salts through diarrhea that is life-threatening.
rehydration solution, developed by the World health Organization, is a mixture
of sugar and salts, which is mixed with clean water and drunk in large amounts.
In some cases, intravenous rehydration may be required. With prompt treatment,
fatality is rare.
Antibiotics may diminish the severity and duration of
the illness, rehydration is the life saver.
Anyone who develops severe diarrhea
and vomiting in cholera areas should seek immediate medical attention.
there a way to prevent infection?
- Avoid unnecessary travel to affected
- Drink boiled water or water treated with chlorine or iodine, or
drinks made with boiled water or carbonated, bottled beverages.
- Do not
add ice to drinks; the ice may be contaminated
- Eat foods that have been
thoroughly cooked and are still hot, or freshly peeled fruit.
- Avoid undercooked
or raw fish or shellfish, including ceviche.
- Avoid salads.
foods and beverages from street vendors.
- If in any doubt, only consume
the items above that you have prepared for yourself.
- Do not bring perishable
What is the cholera vaccine?
vaccine is not recommended for travelers because of the brief and incomplete immunity
it confers. An oral vaccine for cholera has been licensed and is available in
some countries; it appears to provide better immunity with fewer adverse effects
than the previously available vaccine.
Studies have suggested that the use of oral vaccines in endemic areas
can substantially reduce the incidence of the disease.1,2
Not all recipients of the vaccine
will be fully protected against cholera, particularly for certain strains which
no vaccine is effective against. Where effective, the vaccine has a life of a
What is the protocol for cholera vaccination?
risk of cholera to educated and careful travelers is so low that the disadvantesof
vaccination probably outweigh the benefit.
should get vaccinated against cholera?
Currently, no country or territory
requires vaccination against cholera as a condition for entry. in some circumstances,
local authorities may require documentation of this vaccination. A single dose
of oral vaccine will satisfy local requirements.
there adverse reactions to the cholera vaccine?
The most frequently reported
undesirable reactions, such diarrhoea, abdominal pain, abdominal cramps, stomach/abdominal
gurgling (gas), abdominal discomfort, headache, occur in about one in one thousand
Rarer effects (between one and ten in 10,000), include fever, malaise,
nausea, vomiting, loss of /or poor appetite, respiratory symptoms and dizziness.
rare efects include fatigue/drowsiness, flu-syndrome, dyspnoea, dyspepsia, flatulence,
urticaria, shivers, joint pain, sore throat, reduced sense of taste, sweating,
insomnia, dehydration, hypertension, paraesthesia, asthenia, angioedema, fainting,
rash, pruritus, lymphadenitis and arthralgia. Though these are very rare, when
compared with common sense precautions, most people would probably decline a vaccine
that is is not fully effective against many syrains of the disease!
cholera be controlled environmentally?
Although cholera is a potentially
fatal disease, it is easily prevented. In the North America and Western Europe,
cholera is no longer a threat, simply because of modern water supply and sanitation
Simple sanitation is all that is required to avoid an outbreak, and
can often stop an epidemic.
Action needs to be taken at each point of transmission:
sources: Education, and warnings displayed at contaminated water sources.
Boiling, filtering, and chlorination of water before use.
- Affected individuals:
hygiene and safe and efficient disposal of waste.
- Sewage: Treatment of
raw sewage before release into the environment.
Education and sanitation
are the key weapons in the prevention of cholera.
there legal protection for workers and others?
Cholera is usually a gepgraphic
risk, as much as a behavioural one; those who travel to affected areas need to
heed advice and take precautions; in most cases, a legal fight for compensation
would have little hope of success.
But being infected with cholera in a
non-cholera area may well be the result of negligence in water supply, food preparation,
or perhaps hygiene. Take advice!
What can be learned
For one hundred years, cholera and its means of spread have
benn fully understood. And yet scientists still speak of sixth, seventh and eighth
epidemic; academically, they are, of course, correct. But for such a readily preventable
disease, microscopic differences in bug types are nothing, compared to dealing
with dirty water.
"History repeats itself, first as tragedy, second
as farce." - But we can choose to learn from the tragedy, and avoid the farce.
It would be a shame in thirty years, to have to say "What experience and
history teach is this - that people and governments never have learned anything
from history, or acted on principles deduced from it."
and Further Information Sources
, I. M.,
et al., (2007) Controlling Endemic Cholera with Oral Vaccines
PLoS Med. 2007 November; 4(11): e336
- Reyburn, R., et al., (2011) The Case for Reactive Mass Oral Cholera
PLoS Negl Trop Dis. 2011 January; 5(1): e952
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Article written by Andrew Heenan BA (Hons), RGN, RMN